흰점박이꽃무지 유충 추출물이 Co-60 감마선에 조사된 수컷 흰쥐의 혈구 및 전립선에 미치는 방사선 방호효과

• 영문명: Radiation Protection Effect of Protaetia Brevitarsis Larvae Extracts on Blood and Prostate in Male Rats Irradiated with Co-60 Gamma-ray
• 발행기관: 대한방사선과학회(구 대한방사선기술학회)
• 저자명: 정근우(Jeong Geun-Woo) 김장오(Kim Jang-Oh) 이윤지(Lee Yoon-Ji) 김해숙(Kim Hae-Suk) 전찬희(Jeon Chan-Hee) 최제경(Choi Jae-Gyeong) 주성현(Joo Sung-Hyun) 민병인(Min Byung-In)
• 간행물 정보: 『방사선기술과학』방사선기술과학 제44권 제2호, 117~122쪽, 전체 6쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2021.04.30

영문 초록

This study is desinged to examine for radiation protection effect of Protaetia Brevitarsis Larvae extracts on the blood and prostate of male rat as a natural radiation protection agent. 5 groups were classified using 90 male rat as experimental animals. Each group was clssified as normal control group (NC Group), the group administered protaetia brevitarsis larvae extracts (PBE Group), irradiated group (IR Group), irradiated group after administration of protaetia brevitarsis larvae extracts (PBE+IR Group), the group administered protaetia brevitarsis larvae extracts after irradiaton (IR+PBE Group). In IR Group, 7 Gy/h of Co-60 gamma ray was irradiated to SD rats. In PBE+IR Group, protaetia brevitarsis larvae extacts wewe injected at 200 mg/kg/day for 14 days before irradiation, In IR+PBE Group, protaetia brevitarsis larvae extract was injeted after irradiation. On the 1, 7 and 21 days after irradiation, the experimental animals were sacrificed to evaluate the changes in blood cell component, superoxide dismutase (SOD) activity, histopathological evaluation of the liver and prostate gland. As a result, the PBE+IR Group and IR+PBE Group showed a significantly recovery of white blood cell (p<0.01, p<0.01), platelet (p<0.01, p<0.01) than the IR Group. It was also confirmed that SOD activity of PBE+IR Group (p<0.01) and IR+PBE Group (p<0.01) was significantly increased than the IR Group. Also PBE+IR Group and IR+PBE Group showed less inflammatory reactions of cystoplasm in the prostate gland than the IR Group. In conclusion, the protaetia brevitarsis larvae have radioprotection effect against blood and prostate gland. It is expected to be useful for research of radiation protection agent.

목차

Ⅰ. 서 론

Ⅱ. 대상 및 방법

Ⅲ. 결 과

Ⅳ. 고 찰

Ⅴ. 결 론

키워드

흰점박이꽃무지 유충 방사선방호제 항산화 방사선방호효과 전립샘 Protaetia brevitarsis larvae Radioprotector Antioxidant Radioprotection effect Prostate gland