ODA project - Develop Cooperation between Viet Nam and Korea in Agriculture

• 영문명: ODA project - Develop Cooperation between Viet Nam and Korea in Agriculture
• 발행기관: 한국자원식물학회
• 저자명: Khoa, Hoang Viet Bach Le, Le Ba Kim, Moung-Su Byeon, Ji-Hui Lim, Jong-Min Jang, Hye-Ri Cho, Joon-Hyeong
• 간행물 정보: 『한국자원식물학회 학술심포지엄』2011년도 임시총회 및 추계학술발표회, 15~15쪽, 전체 1쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2011.10.31

영문 초록

Melanogenesis is a well-known physiological response of human skin that may occur because of exposure to ultraviolet light, for genetic reasons, or due to other causes. In our effectors to find new skin lightening agents, acanthoic acid (AA) was investigated for its ability to inhibit melanogenesis. The effects of AA isolated from A.koreanumun the expression of $\alpha$-MSH-induced melanogenic factors (tyrosinase, tyrosinase related protein (TRP)-1, TRP-2 and MITF (microphthalmla-associated transcriptional factor)) were investigated in murine B16F10 melanoma cells. The results indicate that AA was an effective inhibitor of melanogenesis in B16F10 cells. To elucidate the mechanism of the effect of AA on melanogenesis, we performed Western blotting for melanogenic proteins. AA inhibited melanogenic factors (tyrosinase, TRP-1, TRP-2) expressions. In this study, we also confirmed that AA decreased the protein level of MITF proteins, which would lead to a decrease of tyrosinase and related genes in B16F10 melanoma cells. In order to apply AA to the human skin, the cytotoxic effects of the AA were determined by MTT assays using human keratinocyte HaCaT cells. Based on these results, we suggest that AA be considered possible anti-melanogenic agent and might be effective against hyperpigmentation disorders for the topical application.

키워드

Acanthopanax koreanum melanogenic factors acanthoic acid B16F10cells HaCaT