Inhibitory Effects of Ethanol Extract from Angelica tenuissima Root on Oxidative Stress and Melanogenesis

• 발행기관: 한국자원식물학회
• 저자명: Hyun Jung Koo Sung Ryul Lee Yuna Park Jin Woo Lee Gyeongseop So Sung Hyeok Kim Chang Woo Ha Sang Eun Lee Jong Phil Bak Su Ryeon Ham Hyosun Lim Youn Kyu Kim Eun-Hwa Sohn
• 간행물 정보: 『한국자원식물학회지』제31권 제4호, 312~321쪽, 전체 10쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2018.08.30

영문 초록

Angelica tenuissima, also known as Ligusticum tenuissimum, is classified as a food-related plant and has been used as traditional medicines treating headache and anemia in Asia. However, its anti-melanogenic effect has not been reported in detail. When the extract of Angelica tenuissima (ATE) was prepared by the extraction with 70% EtOH at 80°C (final yield = 22%), the contents of decursin and Z-ligustilide in ATE were determined 0.06% and 8.43%, respectively. Total flavonoid and phenolic content in mg ATE were 5.52±0.07 ㎍ quercetin equivalents and 237.27±13.24 ㎍ gallic acid equivalents, respectively. Antioxidant capacity of ATE determined by DPPH and ABTS assay was increased with a dose dependent manner up to 1000 ㎍/㎖. The amount of melanin synthesis followed by α-melanocyte stimulating hormone on B16F10 cells were significantly reduced in the presence of ATE (250 to 1000 ㎍/㎖, p<0.05). ATE (125 to 1000 ㎍/㎖, p<0.05) suppressed the tyrosinase activity but did not show any significant effect on α-glucosidase activity at the same condition. Taken together, ATE possesses tyrosinase inhibitory potential with significant antioxidant capacities. These effects of ATE might be involved in suppression of melanin synthesis, at least, in B16F10 cells. The anti-melanogenic potential of ATE will provide an insight into developing a new skin whitening product.

목차

Introduction

Materials and Methods

Results

Discussion

Acknowledgments

References

키워드

Angelica tenuissima Nakai Anti-melanogenic Anti-oxidant Decursin α-Glucosidase Melanin Tyrosinase Z-Ligustilide