Salivary biomarkers in oral squamous cell carcinoma

• 발행기관: 대한구강악안면외과학회
• 저자명: Truc Thi Hoang Nguyen Buyanbileg Sodnom-Ish Sung Weon Choi Hyo-Il Jung Jaewook Cho Inseong Hwang Soung Min Kim
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제46권 제5호, 301~312쪽, 전체 12쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2020.10.30

영문 초록

In disease diagnostics and health surveillance, the use of saliva has potential because its collection is convenient and noninvasive. Over the past two decades, the development of salivary utilization for the early detection of cancer, especially oral cavity and oropharynx cancer has gained the interest of the researcher and clinician. Until recently, the oral cavity and oropharynx cancers are still having a five-year survival rate of 62%, one of the lowest in all major human cancers. More than 90% of oral cancers are oral squamous cell carcinoma (OSCC). Despite the ease of accessing the oral cavity in clinical examination, most OSCC lesions are not diagnosed in the early stage, which is suggested to be the main cause of the low survival rate. Many studies have been performed and reported more than 100 potential saliva biomarkers for OSCC. However, there are still obstacles in figuring out the reliable OSCC salivary biomarkers and the clinical application of the early diagnosis protocol. The current review article discusses the emerging issues and is hoped to raise awareness of this topic in both researchers and clinicians. We also suggested the potential salivary biomarkers that are reliable, specific, and sensitive for the early detection of OSCC.

목차

I. Introduction

II. Salivary Biomarkers

III. Liquid Biopsy of OSCC

IV. Relations with Other Serum Biomarkers

V. Suggested Salivary Biomarkers, Present and Future

VI. Conclusion with Future Trends

References

키워드

Squamous cell carcinoma of head and neck Mouth neoplasm Saliva Biomarkers