학술논문
Insight into the pathogensis of polycystic ovarian syndrome
이용수 9
- 영문명
- 발행기관
- 대한의학유전학회
- 저자명
- Yong Wook Jung Gun Ho Lee You Jung Han Dong Hyun Cha
- 간행물 정보
- 『대한의학유전학회지』제17권 제1호, 1~10쪽, 전체 10쪽
- 주제분류
- 의약학 > 기타의약학
- 파일형태
- 발행일자
- 2020.06.30
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국문 초록
영문 초록
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women, which is characterized by the oligo/ anovulation, hyperandrogenism (HA) and polycystic ovarian morphology which are diagnostic criteria. PCOS has diverse clinical aspects in addition to those diagnostic criteria including increased risk for cardiovascular diseases, metabolic syndrome, dyslipidemia, type 2 diabetes and impaired fertility. Because of the heterogeneity of the disease, the pathogenesis of the disease has not been elucidated yet. Therefore, there is no cure for the endocrinopathy. HA and insulin resistance (IR) has been considered two major pillars of the pathogenesis of PCOS. Recent advances in animal studies revealed the critical role of neuroendocrine abnormalities in developing PCOS. Several pathways related to neuroendocrine origin have been investigated such as hypothalamus pituitary ovarian axis, hypothalamus pituitary adrenal axis and hypothalamus pituitary adipose axis. This review summarizes the current knowledge about the role of HA and IR in developing PCOS. In addition, we review the results of recent genome wide association studies for PCOS. This new perspective improves our understanding of the role of neuroendocrine origins in PCOS and suggest a novel potential therapeutic target for the treatment of PCOS.
목차
Introduction
Hyperandrogenism
Insulin Resistance
Neuroendocrine Abnormality: An Attention Grabbing Pathogenesis of Polycystic Ovarian Syndrome
Neuroendocrine Abnormalities of Hypothalamus Pituitary Adrenal Axis, in PCOS
Neuroendocrine Abnormalities of Hypothalamus Pituitary Ovarian Axis in PCOS
Neuroendocrine Abnormalities of Hypothalamus Pituitary Adipose Axis in PCOS
Current Research in Genetic Basis of PCOS
Conclusion
Acknowledgements
References
키워드
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