Dose-response meta-analysis: application and practice using the R software

• 발행기관: 한국역학회
• 저자명: Sung Ryul Shim Jonghoo Lee
• 간행물 정보: 『Epidemiology and Health』41, 1~7쪽, 전체 7쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2019.01.01

영문 초록

The objective of this study was to describe the general approaches of dose-response meta-analysis (DRMA) available for the quantitative synthesis of data using the R software. We conducted a DRMA using two types of data, the difference of means in continuous data and the odds ratio in binary data. The package commands of the R software were “doseresmeta” for the overall effect sizes that were separated into a linear model, quadratic model, and restricted cubic split model for better understanding. The effect sizes according to the dose and a test for linearity were demonstrated and interpreted by analyzing one-stage and two-stage DRMA. The authors examined several flexible models of exposure to pool study-specific trends and made a graphical presentation of the dose-response trend. This study focused on practical methods of DRMA rather than theoretical concepts for researchers who did not major in statistics. The authors hope that this study will help many researchers use the R software to perform DRMAs more easily, and that related research will be pursued.

목차

INTRODUCTION

UNDERSTANDING DOSE-RESPONSE META-ANALYSIS

DOSE-RESPONSE META-ANALYSIS USING “DOSRESMETA” PACKAGE OF R

CONCLUSION

SUPPLEMENTARY MATERIALS

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS

ORCID

REFERENCES

키워드

Meta-analysis Dose response Quadratic model Restricted cubic spline Nonlinearity Dosresmeta