국내 실외공기의 곰팡이 분포 및 노출에 따른 염증영향평가

• 영문명: Evaluation of Distribution and Inflammatory Effects of Airborne Fungus in Korea
• 발행기관: 한국환경보건학회
• 저자명: 윤원석(Wonsuck Yoon) 임재훈(Jaehoon Lim) 김다사랑(Dasarang Kim) 김승현(Seunghyun Kim) 이효선(Hyo-sun Lee) 김채봉(Chae-Bong Kim) 강주완(Ju-Wan Kang) 이근화(Keun-Hwa Lee) 오인보(Inbo Oh) 김양호(Yangho Kim) 서정욱(Jung-Wook Seo) 홍영습(Young-Seoub Hong) 유 영(Young Yoo)
• 간행물 정보: 『한국환경보건학회지』제45권 제6호, 638~645쪽, 전체 8쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2019.12.30

영문 초록

Objectives: For the risk management of airborne fungal diseases, our aim was to evaluate airborne fungi and study the toxicity associated with fungal allergic diseases using fungal species native to Korea. Methods: Fungi were isolated from outdoor air samples collected from Seoul, Incheon, Cheonan, Gwangju, Ulsan, Busan, and Jeju and tested for their cytotoxicity potential and their ability to induce proliferation and secretion of macrophage-derived chemokine (MDC) in human mast cells (HMC-1). Results: More than 18 species of fungi were collected from outdoor air in Korea over one year, and the strains were identified and systematically analyzed. The results showed that the Cladosporium (59%) and Alternaria (22%) strains are the most common in outdoor air. Three of the collected strains (Fusarium, Trichoderma, and Penicillium) showed mild toxicity in cells involved in allergic inflammation, and twelve induced cell proliferation in HMC-1 cells. More importantly, many strains (Edgeworthia, Trametes, Emmia, Irpex, Talaromyces, Penicillium, Periconia, Epicocum, Bipolaris) induced the MDC protein in activated HMC-1 cells. Conclusion: Nineteen percent of the tested strains caused cytotoxicity in mast cell lines, whereas, most of the non-toxic strains contributed to cell activity. Among the tested strains, more than 80% increased the expression of MDC protein, which contributes to the severity of atopic dermatitis, asthma, and rhinitis. It is, in fact, one of the markers for these conditions. Therefore, airborne fungus could be considered as an important marker for environmental risk management for allergic diseases in Korea.

목차

I. 서 론

II. 연구 방법

III. 결과 및 고찰

IV. 결 론

키워드

Airborne fungus Allergy Fungal diversity Toxicity