Short Term Effects of Topical Cyclosporine and Viscoelastic on the Ocular Surfaces in Patients with Dry Eye

• 발행기관: 대한안과학회
• 저자명: Jun Woong Moon Hyun-Joo Lee Ki Chul Shin Won Ryang Wee Jin Hak Lee Mee Kum Kim
• 간행물 정보: 『The Korean Journal of Ophthalmology』Vol.21 No.4, 189~194쪽, 전체 6쪽
• 주제분류: 인문학 > 역사학
• 파일형태: PDF
• 발행일자: 2007.12.30

영문 초록

Purpose: To compare the short term effects of topical 0.05% cyclosporine (CsA) and a mixture of 0.08% chondroitin sulfate and 0.06% sodium hyaluronate (CS-HA) on dry eye ocular surfaces. Methods: 36 patients with moderate to severe dry eye (5 mm/5 min or less with Schirmer s test or tear break up time (BUT) less than 6 seconds), were treated with topical application of CS-HA on one eye and CsA on the other 4 times a day for 6-8 weeks. BUT, Schirmer s test without anesthesia, and conjunctival impression cytology (CIC; goblet cell density, nucleus to cytoplasmic ratio, and epithelial cell morphology) were evaluated and compared between eyes before and after treatment (repeated measurement of ANOVA). Results: After treatment, BUT and tear wettings were significantly prolonged in each group. Topical CsA treated eyes had greater increase in BUT (p=0.026); there was no significant difference in tear wetting(p=0.132). While the 3 parameters of CIC improved in both groups, goblet cell density was significantlyhigher in eyes treated with CsA (p=0.033). Conclusions: While both CS-HA and 0.05% CsA eyedrops improve ocular surfaces, topical CsA may have a better effect on enhancing tear film stability and goblet cell density.

목차

Materials and Methods

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Discussion

키워드

Dry eye Topical cyclosporine Topical viscoelastic