T2 후두 편평세포암종에서 단독 방사선치료와 항암방사선병합치료의 비교 연구

• 영문명: The treatment outcome of T2 laryngeal squamous cell carcinoma in one institution with long term follow-up: Radiotherapy alone vs Chemoradiotherapy
• 발행기관: 대한두경부종양학회
• 저자명: 진성민(Seong-Min Jin) 김재구(Jae-Gu Kim) 박경석(Kyeong-Suk Park) 정익주(Ik-Joo Chung) 정웅기(Woong-Ki Chung) 이동훈(Dong-Hoon Lee) 이준규(Joon-Kyoo Lee) 임상철(Sang-Chul Lim) 윤태미(Tae-Mi Yoon)
• 간행물 정보: 『대한두경부종양학회지』제34권 제2호, 11~15쪽, 전체 5쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2018.11.30

영문 초록

Background/Objectives: The efficacy of radiotherapy alone versus chemoradiotherapy has been studied in patients with T2N0M0 laryngeal squamous cell carcinoma. Materials & Methods: Thirty nine patients with newly diagnosed T2N0M0 laryngeal squamous cell carcinoma were treated with either radiotherapy(RT group, 66-70Gy) or chemoradiotherapy(CRT group, cisplatin based concurrent chemoradiation with or without 2 cycles induction chemotherapy including cisplatin, 5-FU± docetaxel / radiation therapy same with above mentioned). The mean follow-up was 73.5 months. Results: The overall survival (OS), disease specific survival (DSS), disease free survival (DFS), and larynx preservation survival (LPS) at 5 years were 70%, 79%, 67%, and 71%. The complete response rate was 82.4% in RT group, and was 95.5% in CRT group. OS (57% vs 80%), DSS (69% vs 86%), DFS (52% vs 77%), and LPS (63% vs 77%) at 5 years were higher in CRT group than RT group, but it was not statistically significant. In subsite analysis, CRT group tends to improve DFS, compared to RT group, in glottic cancer (p=0.06). The toxicities were tolerable and no fatal case was observed in both groups. Conclusion: Chemoradiotherapy is effective as primary therapy for T2 laryngeal squamous cell carcinoma and showed manageable treatment induced toxicity.

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Head and neck neoplasms Radiotherapy Chemotherapy