HPV 관련성에 따른 구인두암에서의 positive/close 절제연의 의미

• 영문명: Impact of positive/close margins in oropharyngeal cancer according to the HPV status
• 발행기관: 대한두경부종양학회
• 저자명: 정유석(Yuh-Seog Jung)
• 간행물 정보: 『대한두경부종양학회지』제34권 제2호, 1~9쪽, 전체 9쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2018.11.30

영문 초록

With the emerging knowledge about tumor biology specific for human papillomavirus (HPV)-related head and neck cancers, the classical understanding about the curative surgery in head and neck cancers are starting to progress, customized for their HPV-associations and ultimately specific for tumor biologic characteristics. The common rule for surgery should reflect the biologic characteristics of target tumors, but still, multi-institutional large-scale data could be scarce, due to the subjective feature of surgical treatment itself. However, the impact of HPV for margin determination is now being questioned by multiple groups, and typical example is European Cooperative Oncology Group (ECOG)-3311 study. Here, we review the impact of viral association for surgical decision and its biological background and implications.

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키워드

Surgery Margin Human papillomavirus p16 De-escalation