The two highly immunogenic antigens of Brucella:

• 발행기관: 한국예방수의학회
• 저자명: Alisha Wehdnesday Bernardo Reyes Hannah Leah Tadeja Simborio Huynh Tan Hop Lauren Togonon Arayan Tra
• 간행물 정보: 『Journal of Preventive Veterinary Medicine』Vol.39, No.4, 198~206쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2015.12.30

영문 초록

The bacterial lipopolysaccharide (LPS) mainly contributes to the structural integrity, survival and protection barrier against harsh environments. Therefore, the early stages in LPS or lipid A biosynthesis are attractive targets in the identification and development of inhibitors which would be effective against infections caused by Gram-negative bacteria. The bacterial outer membrane proteins (OMPs) meanwhile function as maintenance for structure, adhesion to other cells and substances, as well as development of resistance to antimicrobials. The LPS and LPS-related molecules, and OMPs are important components of several important pathogens including Brucella, which have been extensively used in studies and in the diagnosis of diseases. Here we review the importance, structure, functions and immunogenic aspects of LPS and OMPs particularly of Brucella which can be targeted for the prevention and diagnosis of brucellosis.

목차

INTRODUCTION

LIPOPOLYSACCHARIDE (LPS)

OUTER MEMBRANCE PROTEINS (OMPs)

CONCLUSION

REFERENCES

키워드

Brucella abortus lipopolysaccharide outer membrane proteins virulence