Distribution and accumulation of Cy5.5-labeled hydrophobically modified glycol chitosan in mice

• 발행기관: 한국예방수의학회
• 저자명: Jung Su Lee Hyeong-Jin Ji Hee-youl Chai Jae-Hwang Jeong Sang Yoon Nam Young Won Yun Beom Jun Lee
• 간행물 정보: 『Journal of Preventive Veterinary Medicine』Vol.39, No.2, 48~57쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2015.06.30

영문 초록

The ultimate goal of this study is to assess the accumulation and distribution of hydrophobically modified glycol chitosan (HGC) as a degradable nanoparticle in the body. To understand the movement of degradable nanoparticle HGC in the body, we intravenously injected a dose of 20 mg/kg of Cy5.5-labeled HGC with size ranging from 320 to 400 nm into ICR mice, and measured the amount of fluorescence remaining in blood and several organs at various time intervals. In blood, the level of Cy5.5-labeled HGC was the highest at 15 min, then after 30 min it decreased rapidly and reached a plateau form 30 min to 28 days. In the tissue we confirmed the presence of nanoparticles at high levels in the order of kidney>liver>submandibular gland until 28 days after injection. However, we did not find the presence of the particles in the brain or testes. These results will provide basic information on HGC as a drug delivery agent.

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Cy5.5-labeled hydrophobically modified glycol chitosan drug delivery agent