Distribution and bioaccumulation of Lu177-labeled hydrophobically modified glycol chitosan in ICR mice

• 발행기관: 한국예방수의학회
• 저자명: Jung Su Lee Hyeong-Jin Ji Hee-youl Chai Jae-Hwang Jeong Sang Yoon Nam Young Won Yun Beom Jun Lee
• 간행물 정보: 『Journal of Preventive Veterinary Medicine』Vol.39, No.2, 58~64쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2015.06.30

영문 초록

This study was conducted to evaluate the accumulation and distribution of hydrophobically modified glycol chitosan (HGC) as a degradable nanoparticle in the body. To determine the movement of degradable HGC nanoparticles in the body, 20 mg/kg of lutetium177-labeled HGC (Lu177-HGC) with the size ranging from 320 to 400 nm was injected intravenously into ICR mice, and the amount of radioactivity remaining in blood and several organs was measured at various time points during the period of 5 days. In the pharmacokinetics analysis using the Lu177 radioisotope, the free Lu177 was mainly distributed and accumulated in the order of kidney>liver>lung at 1 day after the injection of the radioisotope. However, the Lu177-HGC showed a high distribution of nanoparticles in the order of liver>spleen>kidney during the experimental period of 5 days. These results would provide a basic pharmacokinetics for the use of HGC as a drug carrier in drug delivery system.

목차

서 론

재료 및 방법

결 과

고 찰

REFERENCES

키워드

hydrophobically modified glycol chitosan radioisotope lutetium radioactivity