직업적 트리클로로에틸렌 노출과 비호지킨림프종의 연관성

• 영문명: Occupational Exposure to Trichloroethylene and Non-hodgkin Lymphoma Risk
• 발행기관: 한국환경보건학회
• 저자명: 전재범(JaeBuhm Chun) 한소희(Sohee Han) 윤형석(Hyungsuk Yoon) 이은정(Eunjung Lee) 이경무(Kyoung-Mu Lee)
• 간행물 정보: 『한국환경보건학회지』제37권 제5호, 358~369쪽, 전체 12쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2011.10.30

영문 초록

Objectives: In order to evaluate the association between occupational exposure to chloroethylene (TCE) and risk of non-Hodgkin lymphoma (NHL), we conducted a meta-analysis of retrospective cohort studies and casecontrol studies and attempted to summarize the evidence of the association from molecular-epidemiological studies and experiments with human cells. Methods: In the meta-analysis, we restricted the analysis to those studies with data for chlorinated solvents, degreasers, or TCE. Studies involving dry cleaners or launderers were excluded from the analysis because use of TCE as a dry cleaning fluid has been rare since the 1960s. The data were combined using a random-effects model to estimate the summary risks (OR and RR) and 95% confidence intervals (CIs). Molecular evidence of the effect of TCE on human immune system were also reviewed and summarized. Results: Occupational exposure to TCE was strongly associated with NHL among cohort studies (number of studies=13, summary RR=1.33, 95% CI=1.04-1.70) whereas the association was not statistically significant among case-control studies (number of studies=15, summary OR=1.10, 0.98-1.23). When exposure level was considered, it became statistically significant for the highest exposure level (number of studies=5, summary OR=1.70, 1.25-2.32). Molecular evidences showed that TCE exposure in human or cultured human cells may cause a significant decrease immune cell subsets and changes in hormone levels related to immune response. Conclusions: Our results from meta-analysis and additional molecular evidence suggest that occupational exposure to TCE may cause NHL. However, unmeasured potential confounding and unclear dose-response relationships warrant further study on the role of TCE exposure in NHL carcinogenesis.

키워드

Trichloroethylene Non-hodgkin lymphoma Occupational exposure Cohort study Case-control study Immune response Biomarker