부산 지역 임산부의 모체혈, 제대혈, 모유에서 PFOA, PFOS의 농도

• 영문명: Distribution of PFOA and PFOS in Maternal Blood, Cord Blood and Breast Milk in Busan
• 발행기관: 한국환경보건학회
• 저자명: 서춘희(Chunhui Suh) 이채관(Chae Kwan Lee) 김건형(Kunhyung Kim) 손병철(Byung Chul Son) 이종태(Jong Tae Lee)
• 간행물 정보: 『한국환경보건학회지』제38권 제1호, 8~17쪽, 전체 10쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2012.02.28

영문 초록

Objectives: Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are man-made, persistent global pollutants widely diffused throughout the environment. They have been even found in the cord blood and breast milk of humans. Furthermore evidence of developmental toxicity in animals exists. To assess the distribution of maternal and fetal exposure to PFOS and PFOA, we analyzed paired maternal blood, cord blood and breast milk samples. Methods: Maternal blood, cord blood and breast milk were collected from 150 volunteers from the general population (aged 20-40, mean 30.5 ± 2.9) of the city of Busan in 2009-2010. The samples were extracted using the weak anion exchange and solid-phase extraction methods and quantified by high-performance liquid chromatograph (HPLC, Agilent 1200 Series) coupled with an Triple Quad LC-MS/MS system (Agilent 6410). Results: Median PFOA and PFOS concentrations in maternal blood were 2.18 and 3.32 ng/ml, in cord blood were 0.83 and 0.58 ng/ml, and in breast milk were 0.13 and 0.11 ng/ml, respectively. PFOS and PFOA concentrations were significantly correlated among matrices (Spearson s ρ = 0.226, p = 0.05 for maternal blood; ρ = 0.736, p < 0.01 for cord blood; ρ = 0.493 p < 0.01 for breast milk). The ratio of cord blood/maternal blood was 0.39 for PFOA and 0.19 for PFOS. The ratio of breast milk/maternal blood was 0.07 for PFOA and 0.06 for PFOS. Conclusions: Our findings suggest that PFOA and PFOS exposure through the placenta was more prominent than through breast milk among Korean neonates born in Busan. The transfer efficiency of maternal blood to breast milk was similar between PFOA and PFOS, but that of maternal blood to cord blood was higher in PFOA than PFOS.

키워드

Perfluorooctanoic acid Perfluorooctane sulfonate Maternal blood Cord blood Breast milk