가토 두개골에서 β-TCP와 자가골 이식에 관한 실험적 연구

• 영문명: THE EXPERIMENTAL STUDY OF THE BONE REGENERATION ON β-TCP IN RABBIT CRANIAL BONE
• 발행기관: 대한구강악안면외과학회
• 저자명: 이성훈(Sung-Hoon Lee) 송승일(Seung-Il Song) 한지영(Ji-Young Han) 황경균(Kyung-Gyun Hwang) 백승삼(Sung-Sam Paik) 심광섭(Kwang-Sup Shim)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제30권 제4호, 282~291쪽, 전체 10쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2004.08.30

영문 초록

Pure-phase beta-tricalcium phosphate(β-TCP) proved to be a bone regeneration material, providing the patient with vital bone at the defect site in a reasonable time, making a second surgical procedure for bone harvesting unnecessary. This study compares bone healing and BMP 2/4 expression in cranial defects in rabbits grafted with autogenous bone and β-TCP. Thirty New Zealand White rabbits was divided into 3 group of 10 animals each. Bilateral calvarial defects were made in the parietal bones of each animal. β-TCP placed in one defect and the other defects was filled with autogenous bone. The animal were sacrificed at 4, 8 and 12 weeks. Immunohistochemical analysis was used to investigate the expression of BMP 2/4. 1. The new bone formation around autogenous bone from 4 weeks and β-TCP from 8 weeks. 2. In autogenous bone graft, BMP 2/4 expression was decreased from 4 to 12 weeks. 3. In β-TCP graft, BMP 4 expression was increased from 8 to 12 weeks. But, BMP 2 was observed from 12 weeks. This study showed that bone healing, regeneration and, BMP 2/4 expression are delayed in grafted β-TCP than autogenous bone

키워드

Rabbit Cranial bone β-TCP BMP 2/4 Immunohistochemical analysis