당뇨 환자에서 연성 콘택트렌즈 착용에 의한 중심각막두께 및 각막내피세포의 변화

• 영문명: Changes in Central Corneal Thickness and Corneal Endothelial Morphology in Contact Lens-Wearing Diabetic Patients
• 발행기관: 대한안과학회
• 저자명: 강준원 신기철,Joon Won Kang, MD, Ki Cheul Shin, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number10, 1426~1431쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.10.15

영문 초록

Purpose: To evaluate the changes in central corneal thickness and corneal endothelium in contact lens-wearing diabetic patients. Methods: This study included 113 patients who visited the Department of Ophthalmology, Konkuk University Medical Center from August 2006 to August 2007. Ultrasound pachymetry and noncontact specular microscopy were performed on the right eyes of 26 diabetic patients who regularly wore soft contact lenses (group 1), 27 diabetic patients who did not wear soft contact lenses (group 2), 30 soft contact lens-wearers without diabetes mellitus (DM) (group 3), and 30 normal subjects who did not wear soft contact lenses (group 4). Central corneal thickness, corneal endothelial cell density, endothelial cell coefficient of variation, and percentage of hexagonal endothelial cells were compared between the groups. Results: Average duration of diabetes in groups 1 and 2 was 4.38 and 4.41 years, respectively, and average duration of soft contact lens wear in groups 1 and 3 was 5.27 and 3.65 years, respectively. The central cornea was significantly thicker and the endothelial cell density was significantly lower in group 1 than in groups 3 and 4. The cell size coefficient of variation was higher in group 1 than in groups 2 and 4 and higher in group 3 than in group 4. The percentage of hexagonal cells was significantly lower in group 3 than in group 4. Conclusions: Central corneal thickness and endothelial cell density are more affected by DM than contact lens use, and corneal endothelial cell morphology is influenced more by contact lens use than DM. Contact lens use in diabetic patients significantly influences all characteristics of the corneal endothelium compared with those in normal subjects. Patients with DM should be advised not to wear contact lenses.J Korean Ophthalmol Soc 2014;55(10):1426-1431

키워드

Contact lens, Corneal endothelial cell, Corneal thickness, Diabetes mellitus