염증성안와질환에서 Rituximab의 치료 3예

• 영문명: Three Cases of Rituximab Treatment for Orbital Inflammatory Disease
• 발행기관: 대한안과학회
• 저자명: 박병춘 우경인 김윤덕,Byung-Chun Park, MD, Kyung-In Woo, MD, PhD, Yoon-Duck Kim, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume53,number5, 721~727쪽, 전체 7쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2012.05.15

영문 초록

Purpose: To report three cases of rituximab treatment in refractory orbital inflammatory disease. Case summary: Rituximab treatment was performed in three patients (thyroid-associated ophthalmopathy, orbital myositis, and idiopathic sclerosing inflammation) unresponsive to corticosteroid and radiotherapy. One cycle consisted of intravenous infusion of 1000 mg of rituximab, twice at a two-week interval. The patient with thyroid-associated ophthalmopathy exhibited clinical improvement in visual acuity, color vision, visual evoked potential, and visual field after one cycle of rituximab treatment. The patient with orbital myositis improved showed diplopia with a decrease in the size of the extraocular muscle after two cycles of treatment. The patient with idiopathic sclerosing inflammation showed improvements in visual acuity and visual field defect after one cycle of therapy. There were no severe infections or hematologic adverse effects including neutropenia, or decreased immunoglobulin during the follow-up period. Conclusions: Treatment with rituximab appears to offer another therapeutic option in patients unresponsive to corticosteroid or radiotherapy. J Korean Ophthalmol Soc 2012;53(5):721-727

키워드

Inflammation, Orbit, Rituximab, Thyoid