수정체비늘증후군 환자에서 각막내피세포의 변화

• 영문명: Corneal Endothelial Cell Changes in Korean Patients with Exfoliation Syndrome
• 발행기관: 대한안과학회
• 저자명: 노동현 임수호 차순철,Dong Hyoun Noh, MD, Su-Ho Lim, MD, Soon Cheol Cha, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume53,number11, 1649~1656쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.11.15

영문 초록

Purpose: To compare the corneal endothelial cell changes in both eyes of Korean patients with clinically unilateral exfoliation syndrome using specular microscopy. Methods: A total of 144 eyes of 72 patients diagnosed with clinically unilateral exfoliation syndrome at Yeungnam University Hospital between March 2000 and February 2011 were retrospectively reviewed. Comparisons of corneal morphometric analysis were made including endothelial cell density, coefficient of variation, hexagonality, and central corneal thickness between the exfoliative and fellow non-exfoliative eyes in 72 patients with naive unilateral exfoliation syndrome. If patients received intraocular surgery during the follow-up periods, the number of intraocular surgeries and changes of the above-mentioned morphometric analysis were evaluated. Results: The paired exfoliative and fellow non-exfoliative eyes did not differ in endothelial cell density (2587.0 ± 391.0 vs. 2626.8 ± 354.6 cells/mm2, p = 0.321), in the coefficient of variation of cell size (35.9 ± 5.1 vs. 37.1 ± 4.7%), hexagonality (59.5 ± 7.3 vs. 57.8 ± 6.3%), and central corneal thickness (530.5 ± 37.6 vs. 532.0 ± 35.2 μm). However, the exfoliative eyes had significantly higher values for the number of intraocular surgeries (0.97 ± 0.78 vs. 0.28 ± 0.48, p < 0.001) and decrement of corneal endothelial cells (410.9 ± 538.7 vs. 19.0 ± 284.5 cells/mm2, p = 0.007). Conclusions: There were no significant morphologic differences in corneal endothelium between exfoliative eyes and fellow eyes in the present study. However, the authors suggest that specular microscopic examination be performed before intraocular surgery in eyes with exfoliation syndrome when considering the higher frequency of intraocular surgeries and the resultant corneal endothelial damages observed in the present study.

키워드

Cornea, Endothelium, Exfoliation syndrome, Specular microscopy