열공망막박리에서 자가플라스민을 이용한 유리체절제술의 효과

• 영문명: Efficacy of Autologous Plasmin-Assisted Vitrectomy for Rhegmatogenous Retinal Detachment
• 발행기관: 대한안과학회
• 저자명: 박채린 이선호 허장원 정흠,Chaerin Park, MD,, Sun Ho Lee, MD, Jang Won Heo, MD, PhD,, Hum Chung, MD, PhD,
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume52,number7, 825~831쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.07.15

영문 초록

Purpose: To evaluate the efficacy and complication of autologous plasmin (AP) injected before vitrectomy for rhegmatogenous retinal detachment (RRD). Methods: Intravitreal AP injection (0.2 ml) was performed on the eyes without posterior vitreous detachment (PVD) 20 minutes before the vitrectomy for RRD. The extent of PVD was evaluated intraoperatively. Surgical PVD induction was performed and the ease of the procedure was graded. The extent of PVD, ease of PVD induction, and complications (including incidence of iatrogenic retinal break) were compared to those of the control eyes. In order to evaluate complications and measure activated partial thromboplastin time, a microbial culture of injected AP was performed and the rate of postoperative intraocular hemorrhage was investigated. Change in visual acuity and the rate of retinal reattachment were compared in order to evaluate the long-term surgical outcome. Results: The extent of PVD was greater in the AP group than in the control group, and vitreal separation was facilitated by intravitreal AP injection. However, ease of PVD induction and frequency of iatrogenic retinal break found were not significantly different between cases and controls. Neither postoperative intraocular hemorrhage nor systemic coagulation abnormality occurred. Postoperative endophthalmitis and positive microbial culture of the AP solution were also not reported. There was no significant difference in the change in visual acuity and the rate of retinal reattachment between the two groups. Conclusions: Intravitreal AP injection can facilitate vitrectomy for RRD and has no effect on the rate of retinal reattachment. J Korean Ophthalmol Soc 2011;52(7):825-831

키워드

Autologous plasmin, Rhegmatogenous retinal detachment, Vitrectomy