미분화 갑상선암에서의 다병합 치료적 접근

• 영문명: Multimodal Therapeutic Approach in Anaplastic Thyroid Cancer
• 발행기관: 대한내분비외과학회
• 저자명: 서종덕 황규하 정진향 박호용 이영하 Jong Duk Suh M.D. Gyu Ha Hwang M.D. Jin Hyang Jung M.D. Ho Yong Park M.D. and Young Ha Lee M.D.
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』5권2호, 75~80쪽, 전체 6쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2005.12.30

영문 초록

Purpose: Anaplastic thyroid cancer (ATC) is a rare but highly aggressive neoplasm with a dismal prognosis. However, a few patients survive for a long time after treatment. We tried to identify prognostic factors of this disease and analyzed treatment outcomes in patients with ATC. Methods: We reviewed the medical records of 15 patients diagnosed with ATC in our institution between 1988 and 2003. The survival was compared by the Kaplan-Meier log- rank test using SPSS program. Results: The female-to-male ratio was 1.5：1 (9 women and 6 men), and the mean age at diagnosis was 63.9 years (range, 44∼91). The mean tumor size was 6.3 cm (range, 4∼10 cm). Extrathyroidal invasion was present in 12 cases and distant metastasis at diagnosis was present in 6 cases. Surgery was performed in 8 cases. Radiotherapy was used for 10 cases and chemotherapy for 5 cases. The mean overall survival time of the 15 patients was 237 days (range, 28∼717 days). The 6∼, 12∼, 18∼ and 24∼ month survival rates were 33%, 26%, 13% and 0%. No association was found between survival and presenting symptoms, age, gender, tumor size, previous goiter history, extrathyroidal invasion, distant metastasis, surgery, radiotherapy or chemotherapy. A significantly better outcome was observed in patients received triple modality treatment (surgery, radiotherapy and chemotherapy) than in those received single or dual modality treatment (P=0.05). Conclusion: Although most patients with ATC had a poor prognosis, a multimodal approach including surgery, radiotherapy and chemotherapy, might improve survival. (Korean J Endocrine Surg 2005;5:75-80)

키워드

미분화 갑상선암, 예후인자, 치료방법, 생존율,Anaplastic thyroid carcinoma, Prognostic factors, Treatment modalities, Survival rate