마타리 뿌리로부터 분리한 Lignan 화합물의 IL-6 저해활성

• 영문명: Lignans Isolated from the Roots of Patrinia scabiosaefolia F. and their IL(Interleukin)-6 Inhibitory Activity
• 발행기관: 대한약학회
• 저자명: 최은진(Eun Jin Choi) 김청룡(Qinglong Jin) 신지은(Ji Eun Shin) 김현규(Hyun-Gyu Kim) 김정진(Jung Jin Kim) 우은란(Eun-Rhan Woo)
• 간행물 정보: 『약학회지』제53권 제4호 (2009년), 201~205쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.08.31

영문 초록

In an ongoing investigation into anti-inflammatory compounds from natural products, the CH2Cl2soluble fraction of Patrinia scabiosaefolia F. (Valerianaceae) was found to inhibit IL-6 production in TNF-α stimulated MG-63 cell line. By means of a bioassay-directed chromatographic separation technique, lappaol E (1), and nortrachelogenin (2) were isolated. These compounds have been isolated from this plant for the first time. Compounds 1~2 showed potent antioxidative activity using NBT superoxide scavenging assay. Moreover, compound 1 decreased IL-6 production in TNF-α stimulated MG-63 cell line.

키워드

lappaol E nortrachelogenin IL (interleukin)-6 anti-inflammatory activity antioxidative Patrinia scabiosaefolia E.