알록산으로 유도된 당뇨병 토끼에서 겐타마이신의 약물동태 변화

• 영문명: Pharmacokinetic Changes of Gentamycin After Intravenous Administration to Rabbits with Alloxan-Induced Diabetes Mellitus
• 발행기관: 대한약학회
• 저자명: 강태숙(T S Kang) 최준식(J S Choi) 이진환(J H Lee)
• 간행물 정보: 『약학회지』제44권 제6호 (2000년), 539~544쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2000.12.30

영문 초록

Many diabetic patients develop serious complications during the course of the disease, including cardiovascular disorders, nepropathy, neuropathy and retinopathy. Because some physiological changes occurring in diabetes mellitus patients could alter the pharmacokinetics of drugs used to treat the disease, the pharmacokinetics of gentamycin was investigated after intravenous administration (2mg/kg) to control rabbits and acute or chronic alloxan-induced diabetes mellitus rabbits (AIDRs). After intravenous administration, the serum concentrations of gentamycin were significantly higher between 6 and 12hr in chronic AIDRs compared with those in control rabbits. The AUC was significant greater in chronic (31.91+/-3.76mcg/ml.hr) AIDRs than that in control (21.60+/-2.45mcg/ml.hr) rabbits. Total body clearance (CLt) in AIDRs were significantly decreased compared with that in control rabbits. Cumulative urinary excretion of gentamycin was decreased, although not significantly, in AIDRs compared with that in control rabbits.

키워드

Alloxan-Induced acute and chronic diabetes mellitus gentamycin rabbits pharmacokinetics.