Tranylcypromine 광학이성질체에 의한 MAO 자살억제의 반응속도론

• 영문명: Suicidal Inhibition Kinetics of MAO by Tranylcypromine Enantiomers
• 발행기관: 대한약학회
• 저자명: 강건일(Gun Il Kang) 최명희(Myung Hee Choi)
• 간행물 정보: 『약학회지』제33권 제1호 (1989년), 64~71쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1989.02.25

영문 초록

Since time-dependent inactivation of MAO was found to be complete in a few minutes when high concentration ratios of tranylcypromine to MAO were used, a method to obtain kinetic parameters was sought suitable to the conditions in which concentrations of tranylcypromine analogs did not exceed that of MAO. For the purpose, kinetic equations were derived and the method applied to the kinetic studies of tranylcypromine enantiomers. It was found that (E)-(+)-2-phenylcyclopropylamine inhibited MAO by the mechanism following bimolecular reaction scheme with KI of 2.0 X 106M-1min-1. Whereas, MAO-inhibitory pattern of the (-)-enantiomer was to be interpreted by suicide inhibition scheme and measured kin and K'' were 0.457min-1 and 5.4mcM, respectively.