인삼 포리아세틸렌 화합물이 Lymphoid lukemia L1210의 고분자물질 합성에 미치는 영향

• 영문명: Effect of Polyacetylene Compounds from Panax Ginseng on Macromolecule Synthesis of Lymphoid lukemia L1210
• 발행기관: 대한약학회
• 저자명: 김영숙(Young Sook Kim) 김신일(Shin Il Kim) 한덕용(Dug Ryong Hahn)
• 간행물 정보: 『약학회지』제32권 제2호 (1988년), 137~140쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1988.04.29

영문 초록

To investigate polyacetylene compounds isolated from petroleum ether extract of panax ginseng effect on the macromolecule synthesis, lympoid lukemia L1210 cell was incubated with them at 4,8,12,16 hours. Panaxydol, panaxynol and panaxytriol as cytotoxic substances inhibited the synthesis of macromolecule such as DNA, RNA and protein. Panaxydol which had the most potent cytotoxicity among these three compounds showed the strongest inhibitory effect on DNA, RNA and protein synthesis. For DNA and RNA synthesis, panaxynol and panaxytriol decreased the rate of inhibition with the incubation time but panaxydol had a strongest inhibitory effect at 16 hour incubation time. Protein synthesis was markedly inhibited by all these polyacetylene compounds. It was observed that there is a relationship between cytotoxicities of polyacetylene compounds and the inhibition of macromolecule synthesis.