L1210 세포에 대한 제라닐화 후라본의 세포독성

• 영문명: Cytotoxic Activities of some Geranylated Flavones against L1210 Cell
• 발행기관: 대한약학회
• 저자명: 백경업(Kyeong Up Baik) 안병준(Byung Zun Ahn)
• 간행물 정보: 『약학회지』제32권 제2호 (1988년), 125~128쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1988.04.29

영문 초록

Geranylation of some synthetic and natural flavones have yielded cytotoxic products against L1210 cell; 5,2''-dihydroxy-6,7,8-trimethoxy-6''-geranyloxyflavone 4(8.5mcg/ml), 5,6-dihydroxy-7-gerenyloxyflavone 9(2.3mcg/ml). 2 has showed the same range of cytotoxicity as the starting material, 5,2''-dihydroxy-6,7,8-trimethoxy-6''-benzyloxyflavone(17.0mcg/ml). The cytotoxicity of 4 was lower than its starting substance, 5,2'',6''-trihydroxy-6,7,8-trimethoxyflavone(4.5mcg/ml), On geranylating 5,6,7-trihydroxyflavone(baicalein, 15.0mcg/ml) the cytotoxic activity has been strongly potentiated(2.3mcg/ml of 9). The presence of at least a free hydroxy group in B-ring of SkullkApflavone II-type flavones was essential for a high activity. A larger RD-group than methoxy in the B-ring has weakened the activity. The cytotoxicities of baicalein series could not be correlated to their structures.