배의 메탄올 추출물이 마우스의 비장세포 증식능과 Cytokine 생성능에 미치는 영향

• 영문명: Effects of Pear(Pyrus pyrifolia) Methanol Extracts on the Proliferation and the Cytokines Production of Mouse Splenocytes
• 발행기관: 대한약학회
• 저자명: 황유경(Yoo-Kyung Hwang) 표명윤(Myung-Yun Pyo)
• 간행물 정보: 『약학회지』제49권 제1호 (2005년), 25~29쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.02.28

영문 초록

This study was performed to investigate the potential of pear (Pyrus pyrifolia) as a immune-modulating functional food by assay of splenocytes proliferation and induction of cytokines (IFN-γ, IL-4) in vitro. When mouse splenocytes were exposed to various concentration (0.16, 0.31, 0.63, 1.25, 2.50 ㎎/㎖) of pear methanol extracts (P-M) without mitogens, splenocytes proliferation (SP) was significantly increased. Also, SP to mitogens, concanavalin A (Con A) and lipopolysaccharide (LPS) were significantly increased by P-M when compared with controls. When splenocytes were cultured with P-M in the presence of Con A, cytokine (IFN-γ, IL-4) levels in culture supernatant were significantly enhanced in a dose-dependent manner except 2.5 ㎎/㎖ when compared with control group. Therefore, our study suggest that the pear has the potential of being an immune-modulating functional food.

키워드

pear splenocytes proliferation IFN-y IL-4