Isonicotinic acid hydrazide의 Acyl 유도체 합성 및 항균작용에 관한 연구

• 영문명: Studies on the Synthesis and Antitubercular Activity of Acyl Derivatives of Isonicotinic Acid Hydrazide
• 발행기관: 대한약학회
• 저자명: 고현기(Hyun Kee Koh)
• 간행물 정보: 『약학회지』제13권 제1호 (1969년), 43~46쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1969.03.31

영문 초록

Five new acyl derivatives of isonicotinic acid hydrazide such as N-(2, 4-dichlorophenoxyacetyl)-isoniotinic acid hydrazide(I), N-(p-nitrobenzoyl)-isonicotinic acid hydrazide (II), N-benzoylisonicotinic acid hydrazide (III), N-furoylisonicotinic acid hydrazide (IV) and N-(p-aminobenzoyl)-isonicotinic acid hydrazide (V) were synthesized. They were obtained by the action of 2,4-dichlorophenylacetyl chloride, p-nitrobenzoyl chloride, benzoyl chloride, furoyl chloride and p-aminobenzoyl chloride with isonicotinic acid hydrazide in pyridine solution. Evaluated for their in vitro antitubercular activity against Mycobaterium tuberculosis H37 Rv N-furoylisonicotinic acid hydrazide (IV) showed antitubercular activity at 1gammar/ml.