참마 유래 Diosgenin의 혈관 수축성 조절 효과

• 영문명: The Effect of Dioscorea villosa Derived-diosgenin on Vascular Contractility
• 발행기관: 대한약학회
• 저자명: 제현동
• 간행물 정보: 『약학회지』제58권 제5호 (2014년), 337~342쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.10.31

영문 초록

The present study was undertaken to investigate the influence of diosgenin on vascular smooth muscle con- tractility and to determine the mechanism involved. We hypothesized that diosgenin, the primary ingredient of Dioscorea villosa, plays a role in vascular relaxation through inhibition of Rho-kinase in rat aortae. Denuded arterial rings from male Sprague-Dawley rats were used and isometric tensions were recorded using a computerized data acquisition system. Inter-estingly, diosgenin inhibited fluoride-induced contraction but didn't inhibit phorbol ester-induced contraction suggesting that additional pathways different from endothelial nitric oxide synthesis such as inhibition of Rho-kinase might be involved in the vasorelaxation. Furthermore, diosgenin didn't inhibit thromboxane A2-induced increases in pERK1/2 levels suggesting the mechanism excluding inhibition of thromboxane A2-induced increases in ERK1/2 phosphorylation. This study provides evidence that diosgenin induces vascular relaxation through inhibition of Rho-kinase in rat aortae.

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키워드

diosgenin endothelium ERK1/2 fluoride phorbol ester Rho-kinase vasoconstriction