양유(洋乳)의 증숙 및 발효 추출물의 인지능 개선 활성

• 영문명: Cognitive Enhancing Activity of the Steamed and Fermented Extracts of Codonopsis lanceolata Radix
• 발행기관: 대한약학회
• 저자명: 원진배 윤보라 이지우 엄민례 이현용 박동식 정희철 정재윤 마충제
• 간행물 정보: 『약학회지』제57권 제5호 (2013년), 323~329쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.10.31

영문 초록

This study was designed to determine and compare the cognitive enhancing effect of various Codonopsis lan- ceolata extracts by steaming, fermentation and high hydrostatic pressure process. We prepared water extract of C. lanceolata, steamed C. lanceolata, steamed and fermented C. lanceolata and C.lanceolata by high hydrostatic pressure process and fer-mentation. Cognitive enhancing effect of extracts was evaluated in scopolamine-induced memory impairment mice using by passive avoidance test and Morris water maze tests. MTT assay was conducted to investigate neuroprotective effect on glutamate induced cell death in HT22 cells. Steamed and fermented C. lanceolata water extract decreased escape latency in Morris water maze test and increased the latency time of the passive avoidance test compared to other extracts. Fur-thermore, the steamed and fermented C. lanceolata water extract showed neuroprotective effect. These results suggest that steaming and fermentation process more improve cognitive enhancing effect of C. lanceolata than other process.

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키워드

Codonopsis lanceolata steaming ferementation high hydrostatic pressure cognitive enhancing effect neu-roprotective effect