침전극 저주파자극이 흰쥐의 Caspase-3, 9와 Neuronal Nitric Oxide Synthase 면역반응세포 변화에 미치는 영향

• 영문명: The Effect of Needle Electrode Electrical Stimulation on the Change of Caspase-3, 9 and Neuronal Nitric Oxide Synthase Immunoreactive Cells in the Sprague Dawley Rats
• 발행기관: 한국전문물리치료학회
• 저자명: 김수한(Kim Soo-han) 최흥식(Choi Houng-sik) 김택훈(Kim Tack-hoon) 신헌석(Cynn Heon-seock) 김지성(Kim Ji-sung) 송치원(Song Chi-won)
• 간행물 정보: 『한국전문물리치료학회지』한국전문물리치료학회지 제11권 제2호, 47~62쪽, 전체 16쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2004.06.30

영문 초록

In most tissues, apoptosis plays a pivotal role in normal development and in regulation of cell number. Therefore inappropriate apoptosis is revealed in a variety of diseases. This study was carried out to investigate the effects of acupuncture and needle electrode electrical stimulation on the change of caspase-3, 9 and neuronal nitric oxide synthase (nNOS) immunoreactive cells in the Sprague Dawley rats(SD rat). In immobilized SD rats (n=5), enhanced caspase-3 and caspase-9 expression were detected in the reticular part of substantia nigra, and enhanced nNOS was detected in the dorsolateral periaqueductal gray (DL-PAG) of midbrain and the paraventricular nucleus (PVN) of the hypothalamus using immunohistochemistry. Following the immobilization, acupuncture (n=5) and needle electrode electrical stimulation (n=5, 2 ㎐) was applied at Hégŭ (L14) acupoint of SD rats, respectively. The stress-induced enhancement in the expression of caspase-3, 9 and nNOS were The present results demonstrate that and needle electrode electrical stimulation are effective in the modulation of expression of caspase-3, 9 and nNOS induced by immobilization.

목차

Abstract

Ⅰ. 서론

Ⅱ. 연구방법

Ⅲ. 결과

Ⅳ. 고찰

Ⅴ. 결론

인용문헌

키워드

Acupuncture Caspase-3 9 Immobilization Needle electrode electrical stimulation nNOS