TonEBP and SMIT expression in human placenta

• 발행기관: 대한해부학회
• 저자명: Jung-A Shin Hyug-Moo Kwon Ki-Hwan Han Hwa-Young Lee
• 간행물 정보: 『Anatomy and Cell Biology』Vol.45(3), 155~159쪽, 전체 5쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2012.09.30

영문 초록

Tonicity-responsive enhancer binding protein (TonEBP) is a signal transcription factor of transporters such as sodium-myo-inositol cotransporter (SMIT), aldose reductase. TonEBP has a variety of functions such as control of intracellular osmolytes and immunomodulating. It is known that TonEBP is abundant in the placenta, but location and function aren’t known. The aim of this study is to describe the localization of TonEBP in the placenta. We assayed the immunohistochemistry of TonEBP and performed in situ hybridization of SMIT in normal human full term placenta. In normal human full term placenta, TonEBP was in villous trophoblasts, extravillous trophoblasts and some endothelial cells. The result of the in situ hybridization of SMIT was similar to that of immunohistochemistry of TonEBP. Neither TonEBP nor SMIT was present in TonEBP knockout mouse placenta. This shows TonEBP is a key factor in SMIT transcription. TonEBP may play an important role in transporting of inositol to fetus in placenta.

목차

Abstract

Introduction

Materials and Methods

Results

Discussion

References

키워드

TonEBP NFAT5 Sodium-myo-inositol cotransporter Human placenta