Prostate stem cell antigen gene is expressed in islets of pancreas

• 발행기관: 대한해부학회
• 저자명: Hiroe Ono Kazuyoshi Yanagihara Hiromi Sakamoto Teruhiko Yoshida Norihisa Saeki
• 간행물 정보: 『Anatomy and Cell Biology』Vol.45(3), 149~154쪽, 전체 6쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2012.09.30

영문 초록

Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol-anchored cell surface antigen with an organ-dependent expression pattern in cancers; e.g., up-regulated in prostate cancer and down-regulated in gastric cancer. Previously it was reported that PSCA is not expressed in the normal pancreas but aberrantly expressed in pancreatic cancer. In this present study, we identified PSCA expression in islets of the pancreas by immunohistochemistry, which was co-localized with four islet-cell markers: insulin, glucagon, somatostatin and pancreatic polypeptide. In our investigation of the transcription start site of PSCA, we found a non-coding splicing variant of PSCA as well as authentic PSCA transcripts in mRNA samples from a normal pancreas. Both the transcripts were also identified in several pancreatic cancer cell lines. We previously reported that PSCA expression is correlated to the methylation status of the enhancer region in gastric and gallbladder cancer cell lines but not in pancreatic cancer cell lines, suggesting that PSCA expression is regulated in a different mode in pancreatic cancer from that in gastric and gallbladder cancers.

목차

Abstract

Introduction

Materials and Methods

Results

Discussion

Acknowledgements

References

키워드

GPI-anchored protein Islet cells Pancreatic cancer Splicing variant Immunohistochemistry