미세전류자극 강도가 흰쥐의 골관절염 회복에 미치는 영향

• 영문명: The Effect of Microcurrent Stimulation Intensity on Osteoarthritis in Rat
• 발행기관: 한국전문물리치료학회
• 저자명: 진희경(Hee-kyung Jin) 박장성(Jang-sung Park) 김종만(Jong-man Kim)
• 간행물 정보: 『한국전문물리치료학회지』한국전문물리치료학회지 제18권 제1호, 83~92쪽, 전체 10쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2011.02.28

영문 초록

Osteoarthritis is a degenerative joint disease and is led to physical disability. Yet the development of effective disease-modifying treatments has lagged. In this study, I examined the effect of physical therapeutic intervention through microcurrent stimulation and attempt to find which degree of intensity, either 25 ㎂ or 500 ㎂ with a regular 5 pps pulse, is more effective in the osteoarthritis. Osteoarthritis was induced with a mixture of 2% carrageenan and 2% kaolin in 26 male Sprague-Dawley rats. The mixture (0.1 ㎖) was injected into the intra-articular capsule of knee joint once a week for three weeks. Five animals did not show degenerative changes by radiological findings and excluded in the following experiment. Osteoarthritic animals were randomly divided into 3 groups(n₁, n₂, n₃=7/each): untreated, treated with 25 ㎂, treated with 500 ㎂. All experimental groups received microcurrent stimulation for four weeks (15 min/day, 5 days/week). The ethological inspection of foot print analysis on the walking corridor was accomplished every week. Histological preparations and immunohistochemical staining with insulin-like growth factor-1 were also done in the articular cartilages. All of these parameters were compared with those of osteoarthritic control group (n=7). The ethological inspection of foot print analysis revealed that changes of walking track (paw width) and stride length was significantly increased in both experimental groups. The better results were observed in experimental group treated with 25 ㎂ intensity without significance than group treated with 500 ㎂. Histological preparations disclosed that routine hyaline cartilage of articular surface were altered to fibrous cartilage in untreated group and experimental group treated with 500 ㎂ intensity. But a little changes were seen in experimental group treated with 25 ㎂ intensity. Immunolocalization of insulin-like growth factor-1 was simultaneously decreased according to the duration of osteoarthritis, and did not show significant difference among the groups. In this study discovered that the microcurrent stimulation, especially 25 ㎂ intensity, had a positive effect by the ethological inspection, histological and immunohistochemical stainings. These results suggest that microcurrent stimulation with low-intensity might be effective in the promotion of healing process for the osteoarthritis.

목차

Ⅰ. 서론

Ⅱ. 연구방법

Ⅲ. 결과

Ⅳ. 고찰

Ⅴ. 결론

키워드

Articular cartilage Microcurrent intensity Osteoarthritis