척수손상 백서모델에서 저강도 및 중강도 트레드밀 운동이 운동기능회복 및 조직학적 변화에 미치는 영향

• 영문명: Effects of Low and Moderate Intensity Treadmill Exercise on Functional Recovery and Histological Changes After Spinal Cord Injury in the Rats
• 발행기관: 한국전문물리치료학회
• 저자명: 김기도(Gi-do Kim) 김계엽(Gye-yeop Kim) 김은정(Eun-jung Kim)
• 간행물 정보: 『한국전문물리치료학회지』한국전문물리치료학회지 제16권 제2호, 41~49쪽, 전체 9쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2009.05.30

영문 초록

This study was designed to investigate the effects of treadmill exercise of low-intensity and moderate- intensity on the functional recovery and histological change in spinal cord injury (SCI) rats. SCI was induced by the spinal cord impactor dropped after laminectomy. Experimental groups were divided into the Group Ⅰ (normal control), Group Ⅱ (non-treatment after SCI induction), Group Ⅲ (low-intensity treadmill exercise after SCI induction), Group Ⅳ (moderate-intensity treadmill exercise after SCI induction). After operation, rats were tested at modified Tarlov scale at 2 days with divided into 4 groups, and motor behavior test (BBB locomotor rating scale, Grid walk test) was examined at 3, 7, 14, and 21 days. For the observation of damage change and size of the organized surface in spinal cord, histopathological studies were performed at 21 days by H & E, and BDNF(brain-derived neutrophic factor) & Trk-b immunohistochemistry studies were performed at 1, 3, 7, 14, 21 days. According to the results, treadmill exercise can play a role in facilitating recovery of locomotion following spinal cord injury. Specially, moderate-intensity treadmill exercise after SCI induction was most improvement in functional recovery and histological change.

목차

Abstract

Ⅰ. 서론

Ⅱ. 연구방법

Ⅲ. 결과

Ⅳ. 고찰

Ⅴ. 결론

인용문헌

키워드

Histological change Locomotor behavioral test Spinal cord injury Treadmill exercise