Recent advances in vasopressin signaling in the brain: from synapse to behavior to clinical translation

• 발행기관: 대한신경모니터링학회
• 저자명: Hin Kei Kim Seung Hoon Woo
• 간행물 정보: 『Journal of Neuromonitoring & Neurophysiology』Vol.5 No.2, 145~151쪽, 전체 7쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2025.11.30

국문 초록

Arginine vasopressin (AVP) functions not only as a peripheral hormone but also as a potent neuromodulator that shapes neural activity across molecular, circuit, and behavioral levels. In the last few years, powerful tools such as optogenetics, fiber photometry, and receptor-specific imaging have revealed new dimensions of AVP signaling in synaptic plasticity, social behavior, and psychiatric vulnerability. This review integrates discoveries across three tiers, including (1) synaptic-level mechanisms that define how AVP sculpts excitatory–inhibitory balance, (2) behavioral pathways that link AVP activity to social cognition, stress, and emotion, and (3) translational advances identifying receptor-specific therapeutic and imaging strategies. Together, these findings position AVP as a key integrator of homeostatic and social functions in the brain and highlight its emerging clinical potential.

목차

Introduction

Synaptic and Neuronal Mechanisms

Circuit and Behavioral Dynamics

Translational and Clinical Perspectives

Future Directions

Conclusion

Funding

Conflict of Interest

Data Availability

Author Contributions

ORCID

References

키워드

Arginine vasopressin Neurophysiology