Development of a Hyperopia Animal Model Using Blue Light in Guinea Pigs

• 발행기관: 대한안과학회
• 저자명: Yung Ju Yoo Jeong-Min Hwang
• 간행물 정보: 『The Korean Journal of Ophthalmology』Vol.39 No.5, 410~417쪽, 전체 8쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2025.10.30

국문 초록

Purpose: Although numerous studies have investigated the progression of myopia, a reliable animal model for hyperopia remains undeveloped. This study aimed to evaluate whether blue light exposure can suppress emmetropization in a manner comparable to lens-induced hyperopia, thereby facilitating the development of an experimental animal model of hyperopia. Methods: Five-day-old 24 guinea pigs were randomly assigned to four different experimental groups based on light exposure conditions. They were housed under a 12-hour light/dark cycle (lights on at 8 AM and off at 8 PM) and exposed to either white light (control) or blue light (460 ± 20 nm). To induce hyperopia, a custom-designed +10 diopters (D) lens was fabricated using a three-dimensional printer and securely attached to randomly selected one eye with hook-and-loop fasteners and tissue adhesive. Refractive errors, corneal curvature, and axial length were measured using streak retinoscopy and A-scan ultrasound, with repeated measurements to assess intereye deviation. Results: At the end of the treatment period of 6 weeks, guinea pigs reared under blue light with an attached +10 D lens exhibited a significantly greater hyperopic shift compared to those reared under blue light without the lens. In contrast, guinea pigs raised under white light underwent emmetropization regardless of +10 D lens attachment. Conclusions: Blue light exposure significantly suppressed emmetropization by inducing a marked hyperopic shift in guinea pigs, whereas white light conditions support normal emmetropization regardless of lens attachment. These findings suggest that blue light plays a crucial role in hyperopia induction and can be effectively utilized to establish a stable hyperopia animal model.

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키워드

Axial length Blue light Guinea pigs Hyperopia