Treatment Trends of Diabetic Macular Edema in Korea (TRACK) Study: A Prospective Multicenter Study

• 발행기관: 대한안과학회
• 저자명: Min Seok Kim Kwangsic Joo Yong-Un Shin Hee Yoon Cho Joo Yong Lee Min Sagong Jee Taek Kim Yu Cheol Kim Hyun Woong Kim Hyunduck Kwak Seong Joon Ahn Mee Yon Lee Jeong Hun Bae Inyoung Chung Yong Seop Han Woong-Sun Yoo Sung Who Park Do Gyun Kim Hae Min Kang Hee Seung Chin Daniel Duck-Jin Hwang Yong-Sok Ji Kyu Hyung Park
• 간행물 정보: 『The Korean Journal of Ophthalmology』Vol.39 No.5, 399~499쪽, 전체 101쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2025.10.30

국문 초록

Purpose: To evaluate real-world functional and anatomical outcomes, treatment patterns, and ocular examination trends in diabetic macular edema (DME) in Korea. Methods: A prospective, multicenter, observational study was conducted at 17 hospitals (2017–2022) involving adults with DME. Patients were categorized into center-involving DME (CI-DME) and non-CI-DME groups based on optical coherence tomography findings. Serial changes in best-corrected visual acuity (BCVA), central subfoveal thickness (CST), and treatment and examination patterns were recorded at baseline and follow-up visits (6, 12, 18, and 24 months), and analyzed using linear mixed models and paired t-tests. Results: A total of 209 participants (81 female patients, 38.8%; mean age, 60.2 ± 10.8 years) were enrolled. Over 24 months, 10 of 68 non-CI-DME patients (14.7%) developed CI-DME. CST significantly decreased in the CI-DME group (from 419 μm at baseline to 343 μm, p = 0.001), whereas BCVA remained unchanged in both groups. Throughout the 2-year period, the average number of anti–vascular endothelial growth factor (anti-VEGF) injections was 3.1 ± 3.6, while steroid injections averaged 0.7 ± 1.5. The CI-DME group received significantly more anti-VEGF injections compared to the non-CI-DME group (3.8 ± 3.9 vs. 2.0 ± 2.8, p = 0.004). Additionally, the CI-DME group had more frequent visits (15.8 vs. 11.3, p = 0.017) and optical coherence tomography examinations (9.7 vs. 7.4, p = 0.023). The number of anti-VEGF injections decreased in the CI-DME group over time, while the number of visits decreased in both groups. Conclusions: In real-world clinical practice in Korea, the treatment and monitoring frequency for DME was lower than in major clinical trials, potentially contributing to suboptimal visual outcomes.

목차

Materials and Methods

Results

Discussion

Supplementary Materials

References

키워드

Diabetic macular edema Korea Therapeutics