Withdrawal period and time-dependent residues for the tetrachlorvinphos oral product in milk

• 발행기관: 한국예방수의학회
• 저자명: Su Min Nam Do Hui Kim Hyoung Joon Moon Hwan Goo Kang
• 간행물 정보: 『Journal of Preventive Veterinary Medicine』Vol.49, No.3, 122~129쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2025.09.30

국문 초록

This study was conducted to investigate the residue pattern in milk of tetrachlorvinphos oral product used in dairy cows and to suggest an appropriate withdrawal period for the tetrachlorvinphos oral product in milk. The oral product containing tetrachlorvinphos was administered per oral to Holstein dairy cows at a dose of 3.4 g of the active ingredient per 100 kg body weight (maximum dose). Milk was collected at 12-hour intervals during administration and up to 120 hours after termination of administration to determinate tetrachlorvinphos residue in milk by LC-MS/MS. Tetrachlorvinphos residues at each time point and the maximum residue level for tetrachlorvinphos in milk (0.01 mg/kg) were applied to a non-statistical model to establish the withdrawal period of the test product. The recovery, precision, coefficient of determination(R2), limit of detection (LOD) and limit of quantitation (LOQ) of the analytical methods used to quantify tetrachlorvinphos were 98%~104%, 5%~11%, 0.9981~ 0.9991 and 2 µg/kg, 7 µg/kg, respectively. These parameters met all the method validation criteria suggested by the Ministry of Food and Drug Safety and were used as an analytical method for tetrachlorvinphos in milk. When this product was administered to dairy cows at 1x dose by feeding, the tetrachlorvinphos was undetectable in milk (below the limit of detection) in all cows during the dosing period and up to 120 hours after termination of administration. Therefore, we suggest the withdrawal period of this product in milk as 0 days.

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키워드

Tetrachlorvinphos Residue Milk Withdrawal period LC-MS/MS