Association between humidifier disinfectant use duration and lung cancer development in Korea

• 발행기관: 한국역학회
• 저자명: Sungchan Kang Jeong-In Hwang Su Hwan Kim Hyungryul Lim Dong-wook Lee Woojoo Lee Jong Hun Kim Sol Yu Jungyun Lim Younghee Kim Kyoung-Nam Kim
• 간행물 정보: 『Epidemiology and Health』47, 1~8쪽, 전체 8쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2025.01.31

국문 초록

OBJECTIVES: This study was conducted to assess the association between the duration of humidifier disinfectant use and lung cancer development. METHODS: We analyzed data from 3,605 applicants registered for compensation from the Korean government due to health conditions related to humidifier disinfectant exposure. Among these individuals, 121 were diagnosed with lung cancer at least 4 years after their initial exposure (through December 2021). Hazard ratios (HRs) and 95% confidence intervals (CIs) for lung cancer incidence were estimated according to the duration of disinfectant use using Cox proportional hazards models. RESULTS: Compared with <5 months of use, the HRs for lung cancer were 1.81 (95% CI, 0.41 to 7.97) for 5-14 months, 2.45 (95% CI, 0.58 to 10.41) for 15-29 months, and 4.61 (95% CI, 1.12 to 18.91) for ≥30 months. Using never smokers with <15 months of use as the reference category, the HRs were 2.97 (95% CI, 1.34 to 6.56) for never smokers with ≥15 months of use, 2.73 (95% CI, 0.94 to 7.95) for current or former smokers with <15 months of use, and 4.74 (95% CI, 1.94 to 11.61) for current or former smokers with ≥15 months of use. CONCLUSIONS: Our study provides some of the first robust epidemiological evidence that prolonged humidifier disinfectant use contributes to lung cancer development. Future studies—particularly those including unexposed populations—are needed to confirm these findings.

목차

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

NOTES

REFERENCES

키워드

Lung neoplasms Humidifier disinfectants Cox proportional hazards model Polyhexamethylene guanidine phosphate