Effects of Aerobic Exercise on Gene Expression of Skeletal Muscle Related to Aging and Prevention of Chronic Diseases in the Elderly

• 발행기관: 대한운동학회
• 저자명: Tenglong Fan Man-Hsu Lin Siyun Kim Kijin Kim
• 간행물 정보: 『아시아 운동학 학술지』제27권 제3호, 65~74쪽, 전체 10쪽
• 주제분류: 예술체육 > 체육
• 파일형태: PDF
• 발행일자: 2025.07.31

국문 초록

OBJECTIVES This study investigated the effect of aerobic exercise on skeletal muscle gene expression in healthy elderly, and further provided bioinformatics support on aerobic exercise preventing chronic diseases in the elderly. METHODS In this study, researchers downloaded the GSE9103 (gene set enrichment 9103) dataset from the GEO (Gene Expression Omnibus) database. Data of the elderly group was screened by using R, and gene mining was conducted on it to find differential genes. RESULTS The differential genes mainly affect the development of muscle cells in the elderly, actin binding, myosin heavy chain binding, and muscle α-actin binding. A total of 619 differential genes were screened out between the elderly aerobic exercise group and the non-exercise group. GO enrichment analysis shows the effect of aerobic exercise on the biological process, cellular localization, and molecular function in the elderly, mainly on muscle development, actin cytoskeleton, and actin binding. KEGG analysis showed that the pathways affected by differential genes were mainly mineral absorption, MicroRNAs in cancer, estrogen signaling, and pertussis. CONCLUSIONS The up-regulated differential genes and down-regulated differential genes driven by aerobic exercise were helpful for the formation of voluntary exercise awareness in the elderly, prevention of chronic disease, protection from calcium ions overload and cell death induced by oxidative stress, which provide gene targets for aerobic exercise to help the elderly slow down aging and prevent diseases. Meanwhile, the negative impact of the down-regulation of key genes including RPS27A, ACVRL1, ENG, PAIP2, and MLLT4 on the elderly should also be paid attention to in follow-up studies.

목차

Introduction

Materials and Methods

Results

Discussion

Conclusions

References

키워드

Aerobic Exercise Chronic Disease Differential Genes Elderly Skeletal Muscle