Definitive radiotherapy for unresectable extrahepatic cholangiocarcinoma: is it time for an update?

• 발행기관: 대한방사선종양학회
• 저자명: Pervin Hurmuz Alper Kahvecioglu Gokhan Ozyigit Omer Dizdar Mustafa Cengiz
• 간행물 정보: 『대한방사선종양학회지』제43권 제2호, 57~62쪽, 전체 6쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2025.06.30

국문 초록

Purpose: For patients with unresectable extrahepatic cholangiocarcinoma, radiotherapy (RT) is the definitive treatment. In this study, we aimed to evaluate the role of two different RT techniques for definitive treatment of unresectable extrahepatic cholangiocarcinoma. Materials and Methods: Eighteen patients with unresectable extrahepatic cholangiocarcinoma treated with either conventionally fractionated radiotherapy (CFRT) or stereotactic body radiotherapy (SBRT) were evaluated retrospectively. Patients treated with CFRT also received elective nodal irradiation (ENI) in addition to the primary tumor. Results: Median doses of CFRT and SBRT were 50.4 Gy (range, 45 to 59.4) in 25-33 fractions and 37.5 Gy (range, 27.5 to 50) in 3-5 fractions, respectively. Median follow-up was 22 months (range, 7 to 138). During follow-up, local failure occured in one patient (12.5%) in the SBRT group and six patients (60.0%) in the CFRT group (p = 0.041). On the other hand, regional failure occured in five patients (62.5%) in the SBRT group and in two patients (20.0%) in the CFRT group (p = 0.047). Two-year overall survival (OS), local-regional failure-free survival (LRFFS), and distant metastasis-free survival (DMFS) rates were 35.4%, 30.1%, and 24.7%, respectively. Younger age (≤55 years) was associated with better OS, LRFFS, and DMFS. None of the patients experienced ≥grade 3 acute or late toxicity. Conclusion: While SBRT may provide better local tumor control compared to CFRT, the absence of ENI can result in increased regional recurrences. Hence, conducting prospective studies to examine the safety and efficacy of integrating hypofractionated ENI into SBRT is warranted.

목차

Introduction

Materials and Methods

Results

Discussion and Conclusion

Statement of Ethics

Conflict of Interest

Funding

Author Contributions

Data Availability Statement

References

키워드

Cholangiocarcinoma Radiotherapy Lymphatic irradiation Stereotactic techniques