Assessing the Risk of Cognitive Impairment associated with Androgen Receptor Targeting Agent Use in Metastatic Prostate Cancer: A Systematic Review of Real-world Data

• 발행기관: 대한약학회
• 저자명: Haeun Lee Jaehee Jung Hye-Young Kang Chang Wook Jeong Hankil Lee
• 간행물 정보: 『약학회지』제69권 제2호(2025년), 125~134쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2025.04.30

국문 초록

The prevalence of prostate cancer (PC) is increasing, primarily driven by the aging population. Abiraterone and enzalutamide, androgen receptor targeting agents (ARTAs), are currently the leading medications for treating metastatic PC. However, concerns exist regarding cognitive impairment adverse events (AEs) with ARTA use in clinical trials. This systematic review assessed the risk of cognitive impairment AEs associated with abiraterone and enzalutamide using realworld data. A systematic literature search was conducted on July 30, 2023, using PubMed, Embase, and Cochrane. Studies involving PC patients treated with ARTAs were included. Information extracted included the first author’s name, publication year, country, number of patients, age, observation period, database used, cognitive function measurement tools, and cognitive function-related AE outcomes. Quality assessment used the Revised Risk of Bias Assessment Tool for Nonrandomized Studies of Interventions 2 (ROBANS2). A qualitative synthesis of data from 8,872 patients across eight studies revealed no significant risk of cognitive impairment when comparing abiraterone and enzalutamide respectively with other agents. However, in five studies comparing abiraterone and enzalutamide, conclusions regarding cognitive impairment differences were unclear. The quality assessment indicated a low risk of bias in target group comparability, target group selection, and outcome assessment. Further quantitative synthesis using consistent cognitive function measures is necessary to objectively assess the risk of cognitive impairment associated with enzalutamide compared with abiraterone in a realworld setting.

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Acknowledgment

Conflict of Interest

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키워드

Cognitive dysfunction Androgens Prostatic neoplasm Drug-related side effects and adverse reactions