소아의 급성 인두편도염에서 항생제 처방 현황

• 영문명: Prescription of Antibiotics in Pediatric Patients with Acute Pharyngotonsillitis
• 발행기관: 대한약학회
• 저자명: 김소현(Sohyeon Kim) 천부순(Pusoon Chun)
• 간행물 정보: 『약학회지』제69권 제1호(2025년), 56~66쪽, 전체 11쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2025.02.28

국문 초록

This study aimed to investigate the patterns of antibiotic prescriptions and the implementation rate of rapid antigen detection tests (RADTs) for treating acute pharyngotonsillitis in children across South Korea. This retrospective cross-sectional study utilized the Health Insurance Review and Assessment Service-National Patient Sample (HIRA-NPS) data. During 2019-2020, the antibiotic prescribing rates for acute pharyngotonsillitis patients were 39.9% (31,338/78,590) for those aged ≤2 years and 44.1% (57,286/129,977) for those aged 3 to 14 years, respectively. The antibiotic prescribing rate for the patients with acute tonsillitis as the main diagnosis was 61.5% (61,693/100,245), with a higher likelihood of receiving antibiotics compared to patients with acute pharyngitis as the main diagnosis (aOR, 2.846; p<0.001). RADTs were performed in 0.04% (51/119,943) of cases with no antibiotic prescriptions and in 0.01% (6/88,624) of cases with antibiotic prescriptions. Among the first-line antibiotics, β-lactam/β-lactamase inhibitor combinations were the most frequently prescribed (49.1%, 4,680/9,531), followed by second-generation cephalosporins (21.1%, 2,009/9,531) and β- lactams (13.0%, 1,240/9,531). Among the oral first-line antibiotics, third-generation cephalosporins were most likely to be continued within 5 days from day one of treatment compared to amoxicillin and amoxicillin/β-lactamase inhibitor combinations (p<0.001). RADT rates were significantly low; however, antibiotic prescribing rates were high among pediatric patients with acute pharyngotonsillitis. Identifying the causative pathogen in pediatric pharyngotonsillitis patients through accurate testing, rather than relying solely on clinical findings, is essential to prevent inappropriate antibiotic prescriptions. Promoting the use of RADTs can help limit broad-spectrum antibiotic use, thereby reducing antibiotic resistance.

목차

서 론(Introduction)

방 법(Methods)

결 과(Results)

고 찰(Discussion)

결 론(Conclusion)

감사의말씀(Acknowledgment)

Conflict of Interest

References

키워드

Acute pharyngotonsillitis Antibiotic prescribing rate Antibiotic prescription Rapid antigen detection test