사이클로트론 in-target을 이용한 [13N]암모니아 주사액의 제조방법 및 품질관리

• 영문명: Production Method and Quality Control of [13N]Ammonia Injection Using Cyclotron In-Target
• 발행기관: 대한핵의학기술학회
• 저자명: 김대홍(Dae-Hong Kim) 김강빈(Kang-Bin Kim) 김정연(Jeong-Yeon Kim) 박민욱(Min-yook Park) 이정훈(Jeong-Hun Lee)
• 간행물 정보: 『핵의학기술』Vol.28 No.2, 125~130쪽, 전체 6쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2024.11.30

국문 초록

Purpose: Our institution, the demand for [13N]ammonia is increasing, so we will introduce the manufacturing process, quality testing, and other processes for [13N]ammonia injection until it is supplied to patients. Materials and Methods: [13N]ammonia is produced by irradiating water containing 5 mmol of ethanol as a target material in a cyclotron manufactured by IBA at about 90 mA for 15 minutes. The quality of the prepared [13N]ammonia injection is tested according to USP standards. Results: The [13N]ammonia injection solution produced in a cyclotron passes through a cartridge and a sterile filter, and the final amount is about 200 mCi on average in about 2 mL volume, and the production time is about 20 minutes. All quality test results met USP standards. Conclusion: [13N]ammonia injection is a drug whose demand is gradually increasing due to its simple manufacturing process and manufacturing time that does not require synthesis equipment, relatively uncomplicated quality testing, and good visual image.

목차

서론

대상 및 방법

결과

고찰

REFERENCES

키워드

[13N]Ammonia Cyclotron Quality control

참고문헌

• J Nucl Med
• Cardiovasc Diagn Ther
• J Nucl Med
• J Nucl Med
• Int J Appl Radiat Isot
• J Radioanal Nucl Chem
• Int J Rad Appl Instrum A
• J Nucl Cardiol