Optogenetics in the study of gustatory processing: mechanisms of taste perception and neural modulation

• 발행기관: 대한신경모니터링학회
• 저자명: Celine Abueva
• 간행물 정보: 『Journal of Neuromonitoring & Neurophysiology』Vol.4 No.2, 103~110쪽, 전체 8쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2024.11.30

국문 초록

Optogenetics has revolutionized the ability to manipulate neuronal activity by precisely controlling light. By introducing light-sensitive proteins into specific neurons, scientists can activate or inhibit them with high temporal precision. This technique has become a powerful tool in studying the gustatory system, allowing real-time exploration of taste pathways and their effects on taste and behavior. Previous methods such as electrophysiology, neuroimaging, and genetic mapping have examined brain processes involved in gustatory processing, but they do not allow the manipulation of specific proteins or their interactions. Optogenetics offers a new approach by enabling the observation and control of neural structures and functions related to taste perception. By mapping the neural networks involved, optogenetics helps us understand the complex interactions between brain areas responsible for taste. This knowledge can potentially lead to treatments for taste disorders and strategies for taste modification, which could address conditions like aversion, obesity, and metabolic diseases. This article reviews recent advancements in optogenetics and discusses how these innovations are reshaping our understanding of taste perception and offering potential therapeutic applications.

목차

Introduction

Basics of Optogenetics

Taste Perception Investigation through Optogenetic Modulation

Applications of Optogenetics in Taste Dysfunction Research

Current Limitations

Future Directions of Optogenetics for Taste Study

Conclusion

Funding

Conflict of Interest

Data Availavility

ORCID

References

키워드

Optogenetics Taste Gustation Light

참고문헌

• J Cell Biol
• Nat Rev Neurosci
• Cell
• Chem Senses
• Nature Methods
• Front Aging Neurosci
• Neuron
• Nature Neuroscience
• Nature
• Nat Commun
• Science
• Nat Commun
• Cell
• Nature
• Chem Senses
• Nature
• Cell
• Am J Physiol Regul Integr Comp Physiol
• eNeuro
• Handb Clin Neurol
• BMC Neurology
• Frontiers in Aging Neuroscience
• Cell Mol Life Sci
• Nat Rev Neurosci
• Nat Methods