Antithyroid Drug-Induced Hepatotoxicity From Chronic Methimazole Consumption Requiring Total Thyroidectomy

• 발행기관: 대한내분비외과학회
• 저자명: Ashley Pekmezian William Cobb Joseph Portoghese
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』24권3호, 85~89쪽, 전체 5쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2024.09.30

국문 초록

Antithyroid drug-induced hepatotoxicity is extremely rare with very few reported cases in the literature. The typical presentation of antithyroid drug-induced hepatotoxicity is acute onset of symptoms from high dose antithyroid medications in middle-aged females. Here we present an 82-year-old male with a 1-month history of jaundice, scleral icterus, choluria, and fatigue. He has a past medical history of Graves’ disease treated with 5 mg methimazole for 6 years. After extensive laboratory and imaging work up from a multi systems specialty approach, the patient was found to have cholestatic liver cirrhosis. Further ruling out benign, malignant, autoimmune, surgical, other pharmacological, or social causes of this cholestatic liver disease we concluded that the patient had hepatotoxicity secondary to methimazole. The patient successfully underwent total thyroidectomy with subsequent levothyroxine supplementation. Pathology was consistent with a normal sized thyroid with parenchymal fibrosis with lymphocytic infiltrates consistent with medically treated Graves’ disease. Post-operatively the patient’s hepatic function is normalizing.

목차

INTRODUCTION

CASE REPORT

DISCUSSION

SUPPLEMENTARY MATERIAL

REFERENCES

키워드

Thyroidectomy Methimazole Antithyroid drug-induced hepatotoxicity Endocrine surgery