Rosa acicularis Leaves Exert Anti-Obesity Activity through AMPK-Dependent Lipolysis and Thermogenesis in Mouse Adipocytes, 3T3-L1 Cells

• 영문명: Rosa acicularis Leaves Exert Anti-Obesity Activity through AMPK-Dependent Lipolysis and Thermogenesis in Mouse Adipocytes, 3T3-L1 Cells
• 발행기관: 한국자원식물학회
• 저자명: 최정원(Jeong Won Choi) 최혁진(Hyeok Jin Choi) 정진부(Jin Boo Jeong)
• 간행물 정보: 『한국자원식물학회지』제37권 제3호, 247~255쪽, 전체 9쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2024.06.30

국문 초록

In this study, we aimed to verify the anti-obesity activity of R. acicularis leaves (RAL) and elucidate its mechanism of action in 3T3-L1 preadipocytes. RAL dose-dependently inhibited the accumulation of lipid droplets and triacylglycerol. RAL did not affect cell proliferation and survival in undifferentiated 3T3-L1 cells, but it inhibited cell proliferation in differentiating 3T3-L1 cells. RAL increased ATGL, p-HSL, and HSL, and decreased perilipin-1 in differentiating 3T3-L1 cells. In addition, RAL reduced lipid droplet accumulation and increased free glycerol content in differentiated 3T3-L1 cells. RAL increased ATGL and HSL in differentiated 3T3-L1 cells. Also, RAL increased p-AMPK, PPARγ, UCP-1, and PGC-1α in differentiating 3T3-L1 cells. AMPK inhibition by compound C attenuated RAL-mediated increase of ATGL, HSL, PPARγ, and UCP-1 in 3T3-L1 cells. Taken together, it is thought that RAL may inhibit lipid accumulation through lipolysis and thermogenesis via the activation of AMPK in adipocytes.

목차

Introduction

Materials and Methods

Results

Discussion

Acknowledgements

Conflicts of Interest

References

키워드

Adipocytes Anti-obesity activity Lipolysis Rosa acicularis Thermogenesis