Using zebrafish as an animal model for studying rare neurological disorders: A human genetics perspective

• 영문명: Using zebrafish as an animal model for studying rare neurological disorders: A human genetics perspective
• 발행기관: 대한의학유전학회
• 저자명: Dilan Wellalage Don Tae-Ik Choi Tae-Yoon Kim Kang-Han Lee Yoonsung Lee Cheol-Hee Kim
• 간행물 정보: 『대한의학유전학회지』제21권 제1호, 6~13쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2024.06.30

국문 초록

Rare diseases are characterized by a low prevalence, which often means that patients with such diseases are undiagnosed and do not have effective treatment options. Neurodevelopmental and neurological disorders make up around 40% of rare diseases and in the past decade, there has been a surge in the identification of genes linked to these conditions. This has created the need for model organisms to reveal mechanisms and to assess therapeutic methods. Different model animals have been employed, like Caenorhabditis elegans , Drosophila, zebrafish, and mice, to investigate the rare neurological diseases and to identify the causative genes. While the zebrafish has become a popular animal model in the last decade, mainly for studying brain development, understanding neural circuits, and conducting chemical screens, the mouse has been a very well-known model for decades. This review explores the strengths and limitations of using zebrafish as a vertebrate animal model for rare neurological disorders, emphasizing the features that make this animal model promising for the research on these disorders.

목차

Introduction

Understanding Zebrafish as a Model Organism in Neuroscience

Candidate Genes and Phenotypical Analysis of Disease-related Mutations

Zebrafish Models for Rare Neurological Disorders

Conclusion

Acknowledgements

Funding

Authors' Contributions

References

키워드

Rare diseases Neurodevelopmental disorders Human genetics Zebrafish