악성 흑색종에서 CGM이 유도하는 세포자멸사와 상피간엽이행 억제 효과

• 영문명: CGM Induces Cell Apoptosis and Inhibits Epithelial-Mesenchymal Transition in Malignant Melanoma Cells
• 발행기관: 한국구강보건과학회
• 저자명: 강해미(Hae-Mi Kang) 문성혁(Seong-Hyeok Moon) 김인령(In-Ryoung Kim) 박봉수(Bong-Soo Park)
• 간행물 정보: 『한국구강보건과학회지』제12권 제2호, 81~87쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2024.06.30

영문 초록

Objectives: This study explored the effects of CGM treatment on malignant melanoma cells, specifically by focusing on its ability to induce apoptosis and alter the expression of proteins involved in epithelial-mesenchymal transition (EMT), a critical process in cancer metastasis. Methods: To assess cell viability and proliferation rates, at MTT assay and colony formation assay were performed. FACS analysis was conducted to confirm cell apoptosis, and JC-1 fluorescent staining was executed. An invasion assay was performed to observe cell invasiveness, and protein expression was validated by western blot analysis. Results: Our findings demonstrated that CGM treatment significantly induced apoptosis in malignant melanoma cells. Additionally, CGM treatment markedly reduced the invasiveness of melanoma cells, as observed in the invasion assays. Western blot analysis revealed that CGM modulated the expression of several critical proteins involved in EMT, thereby disrupting the EMT process which is essential for cancer metastasis. Conclusions: The research findings indicate that CGM inhibits the growth of melanoma effectively induces apoptosis of cancer cells, and suppresses metastasis through EMT inhibition. Therefore, CGM demonstrates significant value as a potential cancer therapeutic agent.

목차

Ⅰ. 서론

Ⅱ. 연구방법

Ⅲ. 연구결과

Ⅳ. 고찰

Ⅴ. 결론

REFERENCES

키워드

Anti-cancer agent Apoptosis CGM EMT Invasion